Table 2 Main reasons for the revisions
| Main issues for the revisions | Revised protocols | Ratio (%) |
|---|---|---|
| Legal and administrative issues | 112 | 30 |
| Information to the patient and consent | 105 | 28 |
| Privacy | 52 | 14 |
| Sample size | 34 | 9 |
| Protocol | 22 | 6 |
| Treatment or clinical issues | 19 | 5 |
| Inclusion criteria | 4 | 1 |
| Others | 26 | 7 |
| Total | 374 | 100 |